Background: In Ayurvedic classics Sneha kalpana is given its own importance. Sneha Kalpana being a prime component where in the active principles of the drug are incorporated into Sneha & are made lipid soluble allowing the molecules to pass through the blood-brain barrier. Aajanmasatmya & Samskarasya anuvartitwa guna makes the ghrita outstanding with advantages easy absorption, assimilation, longer shelf life, & better bioavailability. Saraswata ghrita 1 and 2 are such special herbomineral and polyherbal formulations of Sneha kalpana described in Astanga sangraha and Astanga hrudaya, that are known for their cognitive capabilities (Medhya rasayana). In contrast to SG 2, which consists of eight ingredients mostly kasthoushadis, Ajadugdha, and murchita ghrita, SG 1 consists of 27 ingredients with kasthoushadis, Swarna, and godugdha as its primary constituents. Materials & methods: SG 1 & SG 2 were prepared by general method of preparation & both were analyzed as per the standard protocols. Results: Standardization of SG 1 & SG 2 with remarkable results regarding physicochemical analysis on loss on drying, microbial l imit, refractive index, Saponification value, refractive index, acid value, iodine value, peroxide value, Hptlc, ester value, iodine value, viscosity, specific gravity & Sem-edx, etc were observed. Conclusion: The prepared SG 11 & SG 22 matches the physicochemical parameters being effective & safe, natural alternative to synthetic nootropics, & imparting good therapeutic property. By considering all the analytical parameters, SG 1 proved better than SG 2. Loss on drying exhibited the least moisture content, no rancidity, & microbial count within limits thereby extending the shelf life. The SEM EDX revealed the presence of gold particles, higher ester value, higher refractive index, lower acid value & Decreased Peroxide value proved better quality of SG 1.
SG 1, SG 2, Ghrita, Swarna, Gold, Medhya rasayana, Nootropic activity
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